解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Risk posed by microbial superantigens in triggering or exacerbating SLE in genetically predisposed individuals, thereby altering the response to its treatment strategies, has not been studied. Using streptococcal pyrogenic exotoxin A and staphylococcal enterotoxin B as prototype superantigens, we have demonstrated tha...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8768-4
更新日期:2016-08-01 00:00:00
abstract::Primate complement receptor type 1 (CR1) protein, a single-chain transmembrane glycoprotein, plays an important role in immune adherence and clearing complement-opsonized immune complexes. Here, the mRNA of the porcine primate-like complement receptor (CR1-like) gene was analyzed, and two domain sequences with potenti...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-016-8792-z
更新日期:2016-08-01 00:00:00
abstract::The Caenorhabditis elegans model can be used to study Candida albicans virulence and host immunity, as well as to identify plant-derived natural products to use against C. albicans. Thymol is a hydrophobic phenol compound from the aromatic plant thyme. In this study, the in vitro data demonstrated concentration-depend...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-016-8785-y
更新日期:2016-08-01 00:00:00
abstract::The aim of the present study was to investigate the association between the presence of albuminuria and cytokines profile with biomarkers of endothelial damage and oxidative stress in patients with type 1 diabetes mellitus (DM1). The sample was composed by 35 healthy individuals, 63 DM1 patients with normoalbuminuria ...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-016-8806-x
更新日期:2016-08-01 00:00:00
abstract::Cell-penetrating peptides (CPP) or membrane-translocating peptides such as penetratin from Antennapedia homeodomain or TAT from human immunodeficiency virus are useful vectors for the delivery of protein antigens or their cytotoxic (Tc) or helper (Th) T cell epitopes to antigen-presenting cells. Mice immunized with CP...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-016-8799-5
更新日期:2016-08-01 00:00:00
abstract::The stimulatory natural killer group 2 member D (NKG2D) lymphocyte receptor, initially discovered and expressed mostly on natural killer (NK) cells, T cells and natural killer T cells, can promote tumor immune surveillance. However, with increasing tumor grade, tumors themselves express NKG2D to self-stimulate oncogen...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8769-3
更新日期:2016-06-01 00:00:00
abstract::Acute graft-versus-host disease (aGvHD) is still a major cause of transplant-related mortality after allogeneic stem cell transplantation (ASCT). It requires immunosuppressive treatments that broadly abrogate T cell responses including beneficial ones directed against tumor cells or infective pathogens. Polo-like kina...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8778-2
更新日期:2016-06-01 00:00:00
abstract::Antimicrobial peptide innate immunity plays a central role in the susceptibility to infectious diseases, as has been described extensively in different settings. However, the role that these molecules play in the immunity mediated by polymorphonuclear phagocytes as part of the innate immunity of ageing individuals has...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8689-2
更新日期:2016-04-01 00:00:00
abstract::Long noncoding RNAs (lncRNA) play key roles in regulating autoimmunity and immunity balance. LncRNA TMEVPG1, which is encoded by a gene located near the Ifn gene, contributes to interferon gamma expression. We investigated the expression of TMEVPG1 in patients with Sjögren syndrome (SS) to determine its role in the pa...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8715-4
更新日期:2016-04-01 00:00:00
abstract::This study is one in series determining the potential of RAGE axis (receptor for advanced glycation end products, isoforms, ligands) as a biomarker in multiple sclerosis (MS). We evaluated serum levels of RAGE ligand, the high-mobility group box (HMGB)1 in MS patients, and assessed the correlation between HMGB1 serum ...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8673-x
更新日期:2016-04-01 00:00:00
abstract::Kv1.3 and IKCa1 lymphocyte potassium channels have been implicated as important targets of selective immunomodulation. We compared the alterations in cytokine production upon selective inhibition of Kv1.3 or IKCa1 channels (by MGTX and TRAM, respectively) in healthy donors (HD), RA and AS patients. We also determined ...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8683-8
更新日期:2016-04-01 00:00:00
abstract::The role of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in the exacerbation of inflammatory bowel disease (IBD) is still uncertain. We prospectively investigated the presence of EBV and HCMV infection in both epithelial and immune cells of colonic mucosa of IBD patients, both refractory and responders to...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8737-y
更新日期:2016-02-01 00:00:00
abstract::Research during the last decade has significantly advanced our understanding of the molecular mechanisms at the interface between the nervous system and the immune system. Insight into bidirectional neuro-immune communication has characterized the nervous system as an important partner of the immune system in the regu...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-015-8718-1
更新日期:2015-12-01 00:00:00
abstract::Upon entry to the systemic circulation, neutrophils exhibit a short mean time to cell death. The viability of most cell types in a steady state is preserved by the interplay of the Bcl-2 family of proteins, wherein the anti-apoptotic members inhibit the action of their pro-apoptotic counterparts. Neutrophils, however,...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-015-8655-z
更新日期:2015-06-01 00:00:00
abstract::The follicular helper T cell (Tfh) and IL-21 have been shown to play an important role in many autoimmune diseases. However, less is known about their role in Graves' disease (GD). This study aimed to investigate the expression of Tfhs and related factors (IL-21, IL-21R, CXCR5, and CXCL13) in GD thyroid tissues and to...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8647-z
更新日期:2015-06-01 00:00:00
abstract::Type 1 diabetes (T1D) is a chronic autoimmune disease in which β cells are destroyed. Islet transplantation is the most promising therapeutic treatment for T1D patients. However, allograft rejection and autoimmune reaction have been recognized as primary causes of graft loss after transplantation. Alpha-1-antitrypsin ...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8636-2
更新日期:2015-05-01 00:00:00
abstract::Histones appear in plasma during infectious or non-infectious sepsis and are associated with multiorgan injury. In the current studies, intravenous infusion of histones resulted in their localization in major organs. In vitro exposure of mouse macrophages to histones caused a buildup of histones on cell membranes foll...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-015-8628-2
更新日期:2015-03-01 00:00:00
abstract::Dendritic cells (DCs) are known to play an important role in initiating and orchestrating antimicrobial immunity. Given the fact that candidiasis appears often in immunocompromised patients, it seems plausible that DCs hold the key to new antifungal strategies. One possibility to enhance the potency of DC-based immuno...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-014-8562-8
更新日期:2015-03-01 00:00:00
abstract::Bronchiolitis obliterans organizing pneumonia (BOOP) is defined by buds of granulation tissue within lung distal airspaces. The diagnosis requires the histopathologic evidence of organizing pneumonia along with a suggestive clinical and radiographic pattern. This disorder is characterized by a good response to cortico...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-014-8607-z
更新日期:2015-02-01 00:00:00
abstract::In recent years, there has been a growing interest in the role of immune, alloimmune and autoimmune processes in the pathogenesis of spontaneous preterm birth and recurrent pregnancy loss. The association between an inflammatory response and preterm labor has been established. Indeed, many women suffering from preterm...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-014-8621-1
更新日期:2015-02-01 00:00:00
abstract::In recent years, there has been a profound change in autoimmune diagnostics. From long, tiring and inaccurate manual methods, the art of diagnostics has turned to modern, rapid and automated technology. New antibody tests have been developed, and almost all autoimmune diseases now have some specific diagnostic markers...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-014-8587-z
更新日期:2015-02-01 00:00:00
abstract::The development and increasing diffusion of new vaccinations and global immunization protocols have aroused burning debates about safety of adjuvants and their immunogenicity-enhancing effect in vaccines. Shoenfeld and Agmon-Levin have grouped under the term "autoimmune/inflammatory syndrome induced by adjuvants" (ASI...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-014-8586-0
更新日期:2014-12-01 00:00:00
abstract::The endoplasmic reticulum aminopeptidase 1 (ERAP1) performs a major role in antigen processing, trimming N-terminally extended peptides to the final epitope for presentation by major histocompatibility complex class I molecules. Recent genome-wide association studies have identified single nucleotide polymorphisms (SN...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-014-8576-2
更新日期:2014-12-01 00:00:00
abstract::We describe herein a 61-year-old woman who presented with fever, night sweats and cough. The diagnosis of pneumonia was established, but with symptom recurrence following antibiotic therapy, further diagnostics were performed. Biopsy via bronchoscopy revealed cryptogenic organizing pneumonia, and later on follow-up, a...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-014-8571-7
更新日期:2014-12-01 00:00:00
abstract::Psoriasis is a common chronic T-cell-mediated autoimmune skin disease, and traditional immunotherapies for psoriasis have focused on the direct inhibition of T cells, which often causes toxicity and lacks long-term effectiveness. Safe and effective therapeutic strategies are strongly needed for psoriasis. In this stud...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-014-8521-4
更新日期:2014-10-01 00:00:00
abstract::Monoclonal antibodies (mAb) have been used as targeted treatments against cancer for more than a decade, with mixed results. Research is needed to understand mAb mechanisms of action with the goal of improving the efficacy of currently used mAbs and guiding the design of novel mAbs. While some mAb-induced tumor cell k...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-014-8542-z
更新日期:2014-08-01 00:00:00
abstract::Studies on the biologic and molecular genetic underpinnings of multiple myeloma (MM) have identified the pleiotropic, pro-inflammatory cytokine, interleukin-6 (IL-6), as a factor crucial to the growth, proliferation and survival of myeloma cells. IL-6 is also a potent stimulator of osteoclastogenesis and a sculptor of...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-014-8528-x
更新日期:2014-08-01 00:00:00
abstract::Type I diabetes (T1D) is a chronic autoimmune disease caused by pancreatic β-cell destruction induced by autoantibodies and autoreactive T cells. After significant reduction of the β-cell mass, diabetes sets in and can cause significant complications. It is estimated that more than 3 million Americans have T1D, and it...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-014-8546-8
更新日期:2014-08-01 00:00:00
abstract::This is a journey that began in medical school at Stanford in 1963 and that is still underway, now as faculty member here for the past 40 years. History is by its nature selective, and I chose highlights that reflect on the remarkable progress we have made using the immune system to treat cancer. We will never be sati...
journal_title:Immunologic research
pub_type: 传,历史文章,杂志文章,评审
doi:10.1007/s12026-014-8506-3
更新日期:2014-05-01 00:00:00
abstract::Natural killer (NK) cells are effector cells of the innate immune system that can lyse target cells without prior sensitization and have an important role in host defense to pathogens and transformed cells. A balance between negative and positive signals transmitted via germ line-encoded inhibitory and activating rece...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-014-8493-4
更新日期:2014-05-01 00:00:00
abstract::Joint damage in rheumatoid arthritis (RA) is characterized by cartilage and bone loss resulting in pain, deformity, and loss of joint function. Anti-citrullinated protein antibody (ACPA) has been implicated in RA pathogenesis and predicts radiographical joint damage and clinical severity. Therefore, the purpose of thi...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-013-8479-7
更新日期:2014-01-01 00:00:00
abstract::p-Phenylenediamine (PPD) and Diphenylcyclopropenone (DPCP) are two potent haptens. Both haptens are known to cause delayed-type hypersensitivity, involving a cytokine response and local infiltration of T-cell subpopulations, resulting in contact dermatitis. We investigated the systemic immune effects of PPD and DPCP, ...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-013-8482-z
更新日期:2014-01-01 00:00:00
abstract::CD62L governs the circulation of CD8(+) T cells between lymph nodes and peripheral tissues, whereby the expression of CD62L by CD8(+) T cells promotes their recirculation through lymph nodes. As such, CD62L participates in the fate of adoptively transferred CD8(+) T cells and may control their effectiveness for cancer...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-013-8456-1
更新日期:2013-12-01 00:00:00
abstract::Interleukin (IL)-21 is a member of the γ chain-receptor cytokine family along with IL-2, IL-4, IL-7, IL-9, and IL-15. The effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. IL-21 is secreted by activated CD4 T cells and natural killer T cells. Within CD4 T cells, its secr...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-013-8457-0
更新日期:2013-12-01 00:00:00
abstract::Immunological memory is a hallmark of adaptive immunity, a defense mechanism endowed to vertebrates during evolution. However, an autoimmune pathogenic role of memory lymphocytes is also emerging with accumulating evidence, despite reasonable skepticism on their existence in a chronic setting of autoimmune damage. It ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-013-8448-1
更新日期:2013-12-01 00:00:00
abstract::Pemphigus foliaceus (PF) and Behçet's disease (BD) are immune-mediated conditions which are usually treated with corticosteroids, immunosuppressants, and, when refractory, with biologic agents. In both diseases, interleukin (IL)-6 serum levels are increased driving the immune-mediated inflammatory process. Tocilizumab...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-013-8411-1
更新日期:2013-07-01 00:00:00
abstract::We recently introduced the concept of the infectome as a means of studying all infectious factors which contribute to the development of autoimmune disease. It forms the infectious part of the exposome, which collates all environmental factors contributing to the development of disease and studies the sum total of bur...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-013-8399-6
更新日期:2013-07-01 00:00:00
abstract::CD6 is a cell surface receptor expressed on the majority of T cells and a subset of B cells. When expressed, CD6 contributes to lymphocyte activation through its extracellular domain 1, while adhesion and cellular migration are related to the extracellular scavenger receptor cysteine-rich domain (SRCR-D)-3 of CD6. Ito...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-013-8423-x
更新日期:2013-07-01 00:00:00
abstract::In the last 15 years, the estimated prevalence of autoimmune diseases increased from about 4 to 9.4%. Autoimmune co-morbidity (i.e., the association between two or more autoimmune diseases in the same patient) is present in 0.4-0.5% of the worldwide population, more frequently in patients with multiple sclerosis, rheu...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-013-8418-7
更新日期:2013-07-01 00:00:00
abstract::γδ T cells represent a relevant proportion of T lymphocytes that express T cell receptors (TCRs) encoded by the γ and δ T cell receptor genes. Whereas the most circulating γδ T cell type, Vδ2 T cells, has been described and studied intensively, the potential role of Vδ1 T cells remains largely unclear. Here, we identi...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-013-8390-2
更新日期:2013-05-01 00:00:00